Article
β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy.
Cancer research - 15 Oct 2017
Bucsek Mark J, Qiao Guanxi, MacDonald Cameron R, Giridharan Thejaswini, Evans Lauren, Niedzwecki Brian, Liu Haichao, Kokolus Kathleen M, Eng Jason W-L, Messmer Michelle N, Attwood Kristopher, Abrams Scott I, Hylander Bonnie L, Repasky Elizabeth A
Abstract excerpt
The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We report here that CD8+ T-cell frequency and functional orientation within the tumor microenvironment is regulated by β2-adrenergic receptor (β-AR) signaling in host immune cells. We used three strategies-physiologic (manipulation of ambient thermal environment),...
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