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Single‐cell analysis reveals metastatic cell heterogeneity in clear cell renal cell carcinoma

23 Mar 2021

Abstract excerpt

Renal cell carcinoma (RCC) is one of the leading causes of cancer-related death worldwide. Tumour metastasis and heterogeneity lead to poor survival outcomes and drug resistance in patients with metastatic RCC (mRCC). In this study, we aimed to assess intratumoural heterogeneity (ITH) in mRCC cells by performing a combined analysis of bulk data and single-cell RNA-sequencing data, and develop novel biomarkers for...

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PMID: 33759378
DOI: 10.1111/jcmm.16479

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