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Article

Gestational intermittent hyperoxia rescues murine genetic congenital heart disease in part.

Scientific reports - 23 Mar 2021

Doll Cassandra F, Pereira Natalia J, Hashimi Mustafa S, Grindrod Tabor J, Alkassis Fariz F, Cai Lawrence X, Milovanovic Una, Sandino Adriana I, Kasahara Hideko

Abstract excerpt

Cardiac development is a dynamic process, temporally and spatially. When disturbed, it leads to congenital cardiac anomalies that affect approximately 1% of live births. Genetic variants in several loci lead to anomalies, with the transcription factor NKX2-5 being one of the largest. However, there are also non-genetic factors that influence cardiac malformations. We examined the hypothesis that hyperoxia may be...

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Identifiers

PMID: 33758249
DOI: 10.1038/s41598-021-85569-9
PMCID: PMC7988122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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