Article
Mechanism of caspase-2 activation upon DNA damage.
Doklady. Biochemistry and biophysics - 1 Mar 2016
Aksenova V I, Kopeina G S, Zamaraev A V, Zhivotovsky B D, Lavrik I N
Abstract excerpt
The mechanism of caspase-2 activation in response to DNA damage was studied using human ovarian cancer cells Caov-4 treated with chemotherapeutic agent cisplatin. It was shown that mutations of the three cleavage sites of caspase-2 do not affect the assembly of the macromolecular complex of caspase-2 and its activation, but, conversely, stabilize this complex, most likely, via the inhibition of the dissociation...
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