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Article

Identification of different mechanisms leading to PAX6 down-regulation as potential events contributing to the onset of Hirschsprung disease.

Scientific reports - 16 Feb 2016

Enguix-Riego María Valle, Torroglosa Ana, Fernández Raquel María, Moya-Jiménez María José, de Agustín Juan Carlos, Antiñolo Guillermo, Borrego Salud

Abstract excerpt

Hirschsprung disease (HSCR) is attributed to a failure of neural crest derived cells to migrate, proliferate, differentiate or survive in the bowel wall during embryonic Enteric Nervous System (ENS) development. This process requires a wide and complex variety of molecules and signaling pathways which are activated by transcription factors. In an effort to better understand the etiology of HSCR, we have designed...

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Share to DNA (Cytosine-5-)-Methyltransferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26879676
DOI: 10.1038/srep21160
PMCID: PMC4754768

Genes

PAX6
CDYL
MEIS1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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