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Article

Evolutionary potential of a duplicated repressor-operator pair: simulating pathways using mutation data.

PLoS computational biology - 1 May 2006

Poelwijk Frank J, Kiviet Daniel J, Tans Sander J

Abstract excerpt

Ample evidence has accumulated for the evolutionary importance of duplication events. However, little is known about the ensuing step-by-step divergence process and the selective conditions that allow it to progress. Here we present a computational study on the divergence of two repressors after duplication. A central feature of our approach is that intermediate phenotypes can be quantified through the use of in...

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Identifiers

PMID: 16733549
DOI: 10.1371/journal.pcbi.0020058
PMCID: PMC1464816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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