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DNASE1L3 arrests tumor angiogenesis by impairing the senescence-associated secretory phenotype in response to stress

19 Mar 2021

Abstract excerpt

. DNASE1L3 was found downregulated and negatively correlated with poor prognosis of resectable and unresectable HCC patients. The tissue microarray of HCC revealed the negative association between DNASE1L3 and cancer vasculature invasion. Mechanistically, DNASE1L3 was found to relieve cytoplasmic DNA accumulation under DNA damage stress in HCC cell lines, in turn cell senescence and senescence-associated...

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PMID: 33744849
DOI: 10.18632/aging.202740

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