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Article

Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses

11 Feb 2016

Abstract excerpt

AIMS: Circular RNAs are a subclass of non-coding RNAs detected within mammalian cells. This study was designed to test the roles of a circular RNA circ-Foxo3 in senescence using in vitro and in vivo approaches. METHODS AND RESULTS: Using the approaches of molecular and cellular biology, we show that a circular RNA generated from a member of the forkhead family of transcription factors, Foxo3, namely circ-Foxo3,...

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PMID: 26873092
DOI: 10.1093/eurheartj/ehw001

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