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Article

Architectural control of metabolic plasticity in epithelial cancer cells.

Communications biology - 19 Mar 2021

Al-Masri Maia, Paliotti Karina, Tran Raymond, Halaoui Ruba, Lelarge Virginie, Chatterjee Sudipa, Wang Li-Ting, Moraes Christopher, McCaffrey Luke

Abstract excerpt

Metabolic plasticity enables cancer cells to switch between glycolysis and oxidative phosphorylation to adapt to changing conditions during cancer progression, whereas metabolic dependencies limit plasticity. To understand a role for the architectural environment in these processes we examined metabolic dependencies of cancer cells cultured in flat (2D) and organotypic (3D) environments. Here we show that cancer...

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Identifiers

PMID: 33742081
DOI: 10.1038/s42003-021-01899-4
PMCID: PMC7979883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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