Article
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.
Nature communications - 19 Mar 2021
Zhang Yalan, Varela Luis, Szigeti-Buck Klara, Williams Adam, Stoiljkovic Milan, Šestan-Peša Matija, Henao-Mejia Jorge, D'Acunzo Pasquale, Levy Efrat, Flavell Richard A, Horvath Tamas L, Kaczmarek Leonard K
Abstract excerpt
Mutations in KCNC3, which encodes the Kv3.3 potassium channel, cause degeneration of the cerebellum, but exactly how the activity of an ion channel is linked to the survival of cerebellar neurons is not understood. Here, we report that Kv3.3 channels bind and stimulate Tank Binding Kinase 1 (TBK1), an enzyme that controls trafficking of membrane proteins into multivesicular bodies, and that this stimulation is...
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