Article
Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2021
Brown Derek W, Lan Qing, Rothman Nathaniel, Pluta John, Almstrup Kristian, Dalgaard Marlene D, Greene Mark H, Grotmol Tom, Loveday Chey, Schwartz Stephen M, Turnbull Clare, Wiklund Fredrik, Kanetsky Peter A, Nathanson Katherine L, McGlynn Katherine A, Machiela Mitchell J
Abstract excerpt
BACKGROUND: Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results. METHODS: Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic...
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