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Article

Significance of Leu and Ser in the βDELSEED-loop of Escherichia coli ATP synthase.

International journal of biological macromolecules - 15 Dec 2020

Steiner Amanda, Raheem Samah, Ahmad Zulfiqar

Abstract excerpt

The current study investigated the significance of βLeu-382 and βSer-383 residues in the highly conserved βDELSEED-loop of Escherichia coli ATP synthase. E. coli wild type and mutant enzymes were inhibited by the honeybee venom peptide melittin, which is a known ATP synthase inhibitor. The wild type enzyme was fully inhibited by melittin. Melittin-induced inhibitory profiles of single mutants βL382A/R/Q/D/E and...

Topics

Adenosine Triphosphatases
Amino Acid Motifs
Amino Acid Sequence
Escherichia coli
Escherichia coli Proteins
Leucine
Melitten
Models, Molecular
Mutation
Oxidative Phosphorylation
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Secondary

Serine

Source

Identifiers

PMID: 33736276
DOI: 10.1016/j.ijbiomac.2020.10.133

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