Article
Significance of Leu and Ser in the βDELSEED-loop of Escherichia coli ATP synthase.
International journal of biological macromolecules - 15 Dec 2020
Steiner Amanda, Raheem Samah, Ahmad Zulfiqar
Abstract excerpt
The current study investigated the significance of βLeu-382 and βSer-383 residues in the highly conserved βDELSEED-loop of Escherichia coli ATP synthase. E. coli wild type and mutant enzymes were inhibited by the honeybee venom peptide melittin, which is a known ATP synthase inhibitor. The wild type enzyme was fully inhibited by melittin. Melittin-induced inhibitory profiles of single mutants βL382A/R/Q/D/E and...
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