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Article

The role of new technologies in myeloproliferative neoplasms: Application of next-generation sequencing in myelofibrosis.

International journal of laboratory hematology - 1 Oct 2021

Navrátilová Jana, Palová Miroslava, Szotkowski Tomáš, Hluší Antonín, Katrincsáková Beáta, Papajík Tomáš, Indrák Karel

Abstract excerpt

INTRODUCTION: Driver mutations in Philadelphia chromosome-negative myeloproliferative neoplasms are well known. In the past, whole-genome sequencing identified nondriver mutations in other genes, potentially contributing to evolution of malignant clones. METHODS: Next-generation sequencing was used to assess the presence of any mutations in 14 candidate genes at the point of diagnosis and the resultant impact on...

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PMID: 33734589
DOI: 10.1111/ijlh.13504

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