Article
Molecular characterization of triple-negative myeloproliferative neoplasms by next-generation sequencing.
Annals of hematology - 1 Sept 2022
Maddali Madhavi, Venkatraman Arvind, Kulkarni Uday Prakash, Mani Sathya, Raj Santhosh, Sigamani Elanthenral, Korula Anu, A Fouzia N, Lionel Sharon Anbumalar, Selvarajan Sushil, Manipadam Marie Therese, Abraham Aby, George Biju, Mathews Vikram, Balasubramanian Poonkuzhali
Abstract excerpt
The role of next-generation sequencing (NGS) in identifying mutations in the driver, epigenetic regulator, RNA splicing, and signaling pathway genes in myeloproliferative neoplasms (MPNs) has contributed substantially to our understanding of the disease pathogenesis as well as disease evolution. NGS aids in determining the clonal nature of the disease in a subset of these disorders where mutations in the driver...
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