Article
A Large-Scale Bank of Organ Donor Bone Marrow and Matched Mesenchymal Stem Cells for Promoting Immunomodulation and Transplant Tolerance.
Frontiers in immunology - 1 Jan 2021
Johnstone Brian H, Messner Franka, Brandacher Gerald, Woods Erik J
Abstract excerpt
Induction of immune tolerance for solid organ and vascular composite allografts is the Holy Grail for transplantation medicine. This would obviate the need for life-long immunosuppression which is associated with serious adverse outcomes, such as infections, cancers, and renal failure. Currently the most promising means of tolerance induction is through establishing a mixed chimeric state by transplantation of...
Topics
- Animals
- Biological Specimen Banks
- Bone Marrow Cells
- Bone Marrow Transplantation
- Donor Selection
- Graft Rejection
- Graft Survival
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells
- Histocompatibility
- Humans
- Immunosuppressive Agents
- Mesenchymal Stem Cell Transplantation