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Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model

2 Apr 2019

Abstract excerpt

Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft-versus-host disease (GVHD). However, despite promising results in phase I/II studies, bone marrow (BM-) derived MSCs failed to demonstrate their superiority over placebo in the sole phase III trial reported thus far. MSCs from different tissue origins display different characteristics, but...

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PMID: 31001253
DOI: 10.3389/fimmu.2019.00619

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