Targeted next-generation sequencing supports serrated epithelial change as an early precursor to inflammatory bowel disease-associated colorectal neoplasia.

doi:10.1016/j.humpath.2021.03.002

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Targeted next-generation sequencing supports serrated epithelial change as an early precursor to inflammatory bowel disease-associated colorectal neoplasia.

Human pathology - 1 Jun 2021

Singhi Aatur D, Waters Kevin M, Makhoul Elias P, Parian Alyssa, Lazarev Mark G, Proksell Siobhan S, Dueker Jeffrey M, Schwartz Marc B, Wald Abigail I, Nikiforova Marina N, Montgomery Elizabeth A

Abstract excerpt

Serrated epithelial change (SEC) manifests in patients with long-standing inflammatory bowel disease (IBD) and is characterized by disorganized crypt architecture, irregular serrations, and goblet cell-rich epithelium. The serrated nature of SEC is reminiscent of serrated colorectal polyps, which frequently harbor KRAS/BRAF mutations. SEC is, however, not only histologically distinct from sporadic serrated polyps...

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Targeted next-generation sequencing supports serrated epithelial change as an early precursor to inflammatory bowel disease-associated colorectal neoplasia.

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