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BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease

15 Mar 2021

Abstract excerpt

Alzheimer's disease (AD) is a chronic progressive degenerative disease of the nervous system. Its pathogenesis is complex and is related to the abnormal expression of the amyloid β (Aβ), APP, and Tau proteins. Evidence has demonstrated that bone morphogenetic protein 4 (BMP4) is highly expressed in transgenic mouse models of AD and that endogenous levels of BMP4 mainly affect hippocampal function. To determine...

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PMID: 33723239
DOI: 10.1038/s41420-021-00435-x

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