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Computational insights on the molecular interplay between KRas (G12D mutation) and SOS1 modulated by the inhibitor BI-3406.

PLoS computational biology - 1 Apr 2026

Zeng Juan, Lan Yixuan, Xia Fei

Abstract excerpt

Ras proteins are prominent oncogenes, with KRas mutations found in approximately 80% of cancer cells harboring Ras mutations. The mechanism by which Ras mutations cause cancer remains unclear. Human Son of Sevenless (SOS) promotes the GDP-to-GTP exchange in the inactive GDP-bound Ras (RasGDP) by interacting with RasGDP conformation, thereby leading to the development of human cancer. Elucidating the Ras-SOS...

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Identifiers

PMID: 42054419
DOI: 10.1371/journal.pcbi.1014213
PMCID: PMC13155684

Genes

SOS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Computational insights on the molecular interplay between KRas (G12D mutation) and SOS1 modulated by the inhibitor BI-3406.PMID 42054419Read ↗

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