Article

Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors

2022-07-25

Abstract excerpt

Mutations within Ras proteins represent major drivers in human cancer. In this study, we report the structure-based design, synthesis, as well as biochemical and cellular evaluation of nucleotide-based covalent inhibitors for KRasG13C, an important oncogenic mutant of Ras that has not been successfully addressed in the past. Mass spectrometry experiments and kinetic studies reveal promising molecular properties of...

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Literature Corpus work: daa847c5-983e-5e58-a392-a1323c9b9e13
DOI: 10.1101/2022.07.25.501348

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