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Intricate Genetic Programs Controlling Dormancy in Mycobacterium tuberculosis

1 Apr 2020

Abstract excerpt

Mycobacterium tuberculosis (MTB) displays the remarkable ability to transition in and out of dormancy, a hallmark of the pathogen's capacity to evade the immune system and exploit susceptible individuals. Uncovering the gene regulatory programs that underlie the phenotypic shifts in MTB during disease latency and reactivation has posed a challenge. We develop an experimental system to precisely control dissolved...

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PMID: 32348771
DOI: 10.1016/j.celrep.2020.107577

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