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Article

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.

Acta neuropathologica communications - 31 May 2018

Henderson Michael X, Peng Chao, Trojanowski John Q, Lee Virginia M Y

Abstract excerpt

Mutations in leucine-rich repeat kinase (LRRK2) are the most common cause of heritable Parkinson's disease (PD), and the most common mutations in LRRK2 lead to elevated kinase activity. For these reasons, inhibitors targeting LRRK2 have been the subject of intense research and development. However, it has been difficult to develop preclinical models that recapitulate PD-relevant LRRK2 phenotypes. The primary...

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Identifiers

PMID: 29855356
DOI: 10.1186/s40478-018-0550-0
PMCID: PMC5984465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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