Article
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
Acta neuropathologica communications - 31 May 2018
Henderson Michael X, Peng Chao, Trojanowski John Q, Lee Virginia M Y
Abstract excerpt
Mutations in leucine-rich repeat kinase (LRRK2) are the most common cause of heritable Parkinson's disease (PD), and the most common mutations in LRRK2 lead to elevated kinase activity. For these reasons, inhibitors targeting LRRK2 have been the subject of intense research and development. However, it has been difficult to develop preclinical models that recapitulate PD-relevant LRRK2 phenotypes. The primary...
Topics
- Animals
- Animals, Newborn
- Cells, Cultured
- Corpus Striatum
- Disease Models, Animal
- Embryo, Mammalian
- Enzyme Inhibitors
- Gene Expression Regulation
- Hippocampus
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mesencephalon
- Mice