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Article

Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype.

Metabolism: clinical and experimental - 1 Aug 2018

Liu Huan, Jiang Wenjun, Chen Xueru, Chang Guoying, Zhao Lei, Li Xihua, Zhang Huiwen

Abstract excerpt

BACKGROUND: Sidt2 is an integral lysosomal membrane protein. Previously, we generated a Sidt2 global knockout mouse and found impaired insulin secretion, along with skeletal muscle pathology. METHODS: A mouse model with a muscle-specific knockout of the Sidt2 gene (Sidt2f/fCre) had been generated, to which extensive morphologic study as well as functional study was applied to investigate the direct role of Sidt2...

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Source

Identifiers

PMID: 29752955
DOI: 10.1016/j.metabol.2018.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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