Article
Beyond tobacco: genomic disparities in lung cancer between smokers and never-smokers.
BMC cancer - 3 Aug 2024
Garrido Javiera, Bernal Yanara, González Evelin, Blanco Alejandro, Sepúlveda-Hermosilla Gonzalo, Freire Matías, Oróstica Karen, Rivas Solange, Marcelain Katherine, Owen Gareth, Ibañez Carolina, Corvalan Alejandro, Garrido Marcelo, Assar Rodrigo, Lizana Rodrigo, Cáceres-Molina Javier, Ampuero Diego, Ramos Liliana, Pérez Paola, Aren Osvaldo, Chernilo Sara, Fernández Cristina, Spencer María Loreto, Aguila Jacqueline Flores, Dossetto Giuliano Bernal, Olea Mónica Ahumada, Rasse Germán, Sánchez Carolina, de Amorim Maria Galli, Bartelli Thais F, Nunes Diana Noronha, Dias-Neto Emmanuel, Freitas Helano C, Armisén Ricardo
Abstract excerpt
BACKGROUND: Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10-20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences in both the clinical presentation and the tumor genomic profiles between smokers and never-smokers. For example, the Lung Adenocarcinoma (LUAD) histological subtype in never-smokers...
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