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EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression

12 Mar 2021

Abstract excerpt

ETS homologous factor (EHF) belongs to the epithelium-specific subfamily of the E26 transformation-specific (ETS) transcription factor family. Currently, little is known about EHF's function in cancer. We previously reported that ETS1 induces expression of the ZEB family proteins ZEB1/δEF1 and ZEB2/SIP1, which are key regulators of the epithelial-mesenchymal transition (EMT), by activating the ZEB1 promoters. We...

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PMID: 33712555
DOI: 10.1038/s41389-021-00313-2

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