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Glucose and Insulin-Related Traits, Type 2 Diabetes and Risk of Schizophrenia: A Mendelian Randomization Study.

EBioMedicine - 1 Aug 2018

Li Zhiqiang, Chen Peng, Chen Jianhua, Xu Yifeng, Wang Qingzhong, Li Xingwang, Li Changgui, He Lin, Shi Yongyong

Abstract excerpt

BACKGROUND: The link between schizophrenia and diabetes mellitus is well established by observational studies; however, the cause-effect relationship remains unclear. METHODS: Here, we conducted Mendelian randomization analyses to assess a causal relationship of the genetic variants related to elevated fasting glucose levels, hemoglobin A1c (HbA1c), fasting insulin levels, and type 2 diabetes with the risk of...

Topics

Blood Glucose
Diabetes Mellitus, Type 2
Fasting
Glycated Hemoglobin
Humans
Insulin
Mendelian Randomization Analysis
Odds Ratio
Polymorphism, Single Nucleotide
Risk Factors
Schizophrenia

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Identifiers

PMID: 30100396
DOI: 10.1016/j.ebiom.2018.07.037
PMCID: PMC6116472

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