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Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen

12 Mar 2021

Abstract excerpt

Virus host shifts are generally associated with novel adaptations to exploit the cells of the new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has apparently required little to no significant adaptation to humans since the start of the Coronavirus Disease 2019 (COVID-19) pandemic and to October 2020. Here we assess the types of natural selection taking place...

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PMID: 33711012
DOI: 10.1371/journal.pbio.3001115

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