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Article

Disruption of pathways regulated by Integrator complex in Galloway–Mowat syndrome due to WDR73 mutations

8 Mar 2021

Abstract excerpt

Several studies have reported WDR73 mutations to be causative of Galloway-Mowat syndrome, a rare disorder characterised by the association of neurological defects and renal-glomerular disease. In this study, we demonstrate interaction of WDR73 with the INTS9 and INTS11 components of Integrator, a large multiprotein complex with various roles in RNA metabolism and transcriptional control. We implicate WDR73 in two...

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PMID: 33686175
DOI: 10.1038/s41598-021-84472-7

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