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Article

An affective disorder in zebrafish with mutation of the glucocorticoid receptor.

Molecular psychiatry - 1 Jun 2013

Ziv L, Muto A, Schoonheim P J, Meijsing S H, Strasser D, Ingraham H A, Schaaf M J M, Yamamoto K R, Baier H

Abstract excerpt

Upon binding of cortisol, the glucocorticoid receptor (GR) regulates the transcription of specific target genes, including those that encode the stress hormones corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone. Dysregulation of the stress axis is a hallmark of major depression in human patients. However, it is still unclear how glucocorticoid signaling is linked to affective disorders. We...

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Identifiers

PMID: 22641177
DOI: 10.1038/mp.2012.64
PMCID: PMC4065652

Genes

CRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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