Article
Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2005
Tsai Pei-San, Moenter Suzanne M, Postigo Hector R, El Majdoubi Mohammed, Pak Toni R, Gill John C, Paruthiyil Sreenivasan, Werner Sabine, Weiner Richard I
Abstract excerpt
Increasing evidence suggests that fibroblast growth factors (FGFs) are neurotrophic in GnRH neurons. However, the extent to which FGFs are involved in establishing a functional GnRH system in the whole organism has not been investigated. In this study, transgenic mice with the expression of a dominant-negative FGF receptor mutant (FGFRm) targeted to GnRH neurons were generated to examine the consequence of...
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