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Article

Oligomeric Aβ1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function.

Cells - 17 Feb 2021

Lynn Savannah A, Johnston David A, Scott Jenny A, Munday Rosie, Desai Roshni S, Keeling Eloise, Weaterton Ruaridh, Simpson Alexander, Davis Dillon, Freeman Thomas, Chatelet David S, Page Anton, Cree Angela J, Lee Helena, Newman Tracey A, Lotery Andrew J, Ratnayaka J Arjuna

Abstract excerpt

Alzheimer's disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina with increasing age and in eyes of age-related macular degeneration (AMD) patients. To study Aβ-induced retinopathy, wild-type mice were injected with nanomolar human oligomeric Aβ1-42, which recapitulate the Aβ burden reported in human donor eyes. In vitro studies investigated the cellular effects of Aβ in endothelial and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33671133
DOI: 10.3390/cells10020413
PMCID: PMC7922851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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