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Article

Instability of the NS1 Glycoprotein from La Reunion 2018 Dengue 2 Virus (Cosmopolitan-1 Genotype) in Huh7 Cells Is Due to Lysine Residues on Positions 272 and 324.

International journal of molecular sciences - 16 Feb 2021

Ogire Eva, Diaz Olivier, Vidalain Pierre-Olivier, Lotteau Vincent, Desprès Philippe, Roche Marjolaine

Abstract excerpt

La Reunion island in the South West Indian Ocean is now endemic for dengue following the introduction of dengue virus serotype 2 (DENV-2) cosmopolitan-I genotype in 2017. DENV-2 infection causes a wide spectrum of clinical manifestations ranging from flu-like disease to severe dengue. The nonstructural glycoprotein 1 (NS1) has been identified as playing a key role in dengue disease severity. The intracellular NS1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33669407
DOI: 10.3390/ijms22041951
PMCID: PMC7920422

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