Article
DNA-methylation for the detection and distinction of 19 human malignancies.
Epigenetics - 1 Jan 2000
Danilova Ludmila, Wrangle John, Herman James G, Cope Leslie
Abstract excerpt
The contribution of DNA-methylation based gene silencing to carcinogenesis is well established. Increasingly, DNA-methylation is examined using genome-wide techniques, with recent public efforts yielding immense data sets of diverse malignancies representing the vast majority of human cancer related disease burden. Whereas mutation events may group preferentially or in high frequency with a given histology,...
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