Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML.

doi:10.1038/s41375-021-01192-7

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Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML.

Leukemia - 1 Sept 2021

Gionfriddo Ilaria, Brunetti Lorenzo, Mezzasoma Federica, Milano Francesca, Cardinali Valeria, Ranieri Roberta, Venanzi Alessandra, Pierangeli Sara, Vetro Calogero, Spinozzi Giulio, Dorillo Erica, Wu Hsin Chieh, Berthier Caroline, Ciurnelli Raffaella, Griffin Melanie J, Jennings Claire E, Tiacci Enrico, Sportoletti Paolo, Falzetti Franca, de Thé Hugues, Veal Gareth J, Martelli Maria Paola, Falini Brunangelo

Abstract excerpt

Acute myeloid leukemia (AML) with mutated NPM1 accounts for one-third of newly diagnosed AML. Despite recent advances, treatment of relapsed/refractory NPM1-mutated AML remains challenging, with the majority of patients eventually dying due to disease progression. Moreover, the prognosis is particularly poor in elderly and unfit patients, mainly because they cannot receive intensive treatment. Therefore,...

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PMID: 33654209
DOI: 10.1038/s41375-021-01192-7
PMCID: PMC8410589

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