Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze.

doi:10.1183/13993003.02012-2020

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Article

Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze.

The European respiratory journal - 1 Sept 2021

Knihtilä Hanna M, Kelly Rachel S, Brustad Nicklas, Huang Mengna, Kachroo Priyadarshini, Chawes Bo L, Stokholm Jakob, Bønnelykke Klaus, Pedersen Casper-Emil T, Bisgaard Hans, Litonjua Augusto A, Lasky-Su Jessica A, Weiss Scott T

Abstract excerpt

BACKGROUND: Prenatal vitamin D3 supplementation has been linked to reduced risk of early-life asthma/recurrent wheeze. This protective effect appears to be influenced by variations in the 17q21 functional single nucleotide polymorphism rs12936231 of the child, which regulates the expression of ORMDL3 (ORM1-like 3) and for which the high-risk CC genotype is associated with early-onset asthma. However, this does...

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PMID: 33653805
DOI: 10.1183/13993003.02012-2020
PMCID: PMC8410880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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