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Article

High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 May 2021

Brustad Nicklas, Greve Jens H, Mirzakhani Hooman, Pedersen Casper-Emil T, Eliasen Anders U, Stokholm Jakob, Lasky-Su Jessica, Bønnelykke Klaus, Litonjua Augusto A, Weiss Scott T, Bisgaard Hans, Chawes Bo L

Abstract excerpt

BACKGROUND: Randomized controlled trials (RCTs) suggest a protective effect of high-dose vitamin D supplementation in pregnancy on offspring risk of persistent wheeze, but only in some individuals, which might be explained by variations in vitamin D pathway genes. This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype,...

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Identifiers

PMID: 33453076
DOI: 10.1111/pai.13453

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