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Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia

1 Mar 2021

Abstract excerpt

bacteremia (ARMB). Thus, persistence reflects host-pathogen interactions occurring uniquely in context of antibiotic therapy in vivo. However, host factors and mechanisms involved in APMB remain unclear. We compared DNA methylomes in circulating immune cells from patients experiencing APMB vs. ARMB. Overall, methylation signatures diverged in the distinct patient cohorts. Differentially methylated sites...

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PMID: 33649198
DOI: 10.1073/pnas.2000663118

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