Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Streptococcus pyogenes carriage is associated with distinct in vivo transcriptional states but not carrier-specific genotypes.

Cell reports - 22 Sept 2026

Faiola Nicholas, Wood Jason M, Casab Nicole, Xu May, Quirk Kevin, Thomas Christopher, Klos Eliza, Thesier Jordan, Waldran Mitchell, Maienschein-Cline Mark, Federle Michael J, DeMuri Gregory P, Wald Ellen R, Cook Laura C

Abstract excerpt

Group A Streptococcus (GAS) is a major human pathogen causing extensive global morbidity. While the asymptomatic carrier state challenges clinical management and contributes to community transmission, genomic, and transcriptomic analyses of naturally acquired human GAS carriage have been lacking. In this study, samples are collected from individuals before and after treatment for acute GAS pharyngitis. Selected...

Read the complete abstract on PubMed

Topics

Streptococcus pyogenes
Humans
Genotype
Streptococcal Infections
Carrier State

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transcription, Genetic

Pharyngitis

Gene Expression Regulation, Bacterial

Biofilms

Genome, Bacterial

Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 42671916
DOI: 10.1016/j.celrep.2026.117925
PMCID: PMC13671490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Streptococcus pyogenes carriage is associated with distinct in vivo transcriptional states but not carrier-specific genotypes.PMID 42671916Read ↗

Unraveling <i>Streptococcus pyogenes</i> Carriage: Genomic and Transcriptomic Insights from Acute and Post-Treatment PhasesSemantic proximity Read ↗

Elucidating the role of group A Streptococcus genomics and pharyngeal microbiota in acute paediatric pharyngitisSemantic proximity Read ↗

Insights into <i>Streptococcus Pyogenes</i> Pathogenesis from Transcriptome StudiesSemantic proximity Read ↗

Longitudinal analysis of the group A <i>Streptococcus</i> transcriptome in experimental pharyngitis in cynomolgus macaquesSemantic proximity Read ↗

Streptococcus pyogenes (“Group A Streptococcus”), a Highly Adapted Human Pathogen—Potential Implications of Its Virulence Regulation for Epidemiology and Disease ManagementSemantic proximity Read ↗

Host transcriptional analysis to improve the diagnosis of group A streptococcal pharyngitisSemantic proximity Read ↗

Novel genes required for the fitness of <i>Streptococcus pyogenes</i> in human salivaSemantic proximity Read ↗

Pan-GWAS of <i>Streptococcus agalactiae</i> highlights lineage-specific genes associated with virulence and niche adaptationSemantic proximity Read ↗

Transcriptome remodeling contributes to epidemic disease caused by the human pathogen <i>Streptococcus pyogenes</i>Semantic proximity Read ↗

Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes.Semantic proximity Read ↗

Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human salivaSemantic proximity Read ↗

Genomic Analyses of Pneumococci from Children with Sickle Cell Disease Expose Host-Specific Bacterial Adaptations and Deficits in Current InterventionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.