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Article

Visualization of fidaxomicin association with the exosporium layer of Clostridioides difficile spores.

Anaerobe - 1 Jun 2021

Bassères Eugénie, Endres Bradley T, Montes-Bravo Nicolás, Pérez-Soto Nicolás, Rashid Tasnuva, Lancaster Christopher, Begum Khurshida, Alam M Jahangir, Paredes-Sabja Daniel, Garey Kevin W

Abstract excerpt

BACKGROUND: Fidaxomicin has novel pharmacologic effects on C. difficile spore formation including outgrowth inhibition and persistent spore attachment. However, the mechanism of fidaxomicin attachment on spores has not undergone rigorous microscopic studies. MATERIALS & METHODS: Fidaxomicin attachment to C. difficile spores of three distinct ribotypes and C. difficile mutant spores with inactivation of exosporium...

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Identifiers

PMID: 33640461
DOI: 10.1016/j.anaerobe.2021.102352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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