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Emergence and Spread of Clostridioides difficile Isolates With Reduced Fidaxomicin Susceptibility in an Acute Care Hospital.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 4 Jun 2025

Redmond Sarah N, Cadnum Jennifer L, Jencson Annette L, Kaple Claire E, Wilson Brigid M, Skinner Andrew M, Gargis Amy S, Hwang Munok, Choi Hosoon, Chatterjee Piyali, Jinadatha Chetan, Donskey Curtis J

Abstract excerpt

BACKGROUND: There have been several recent reports of Clostridioides difficile infection (CDI) due to isolates with reduced fidaxomicin susceptibility (minimum inhibitory concentration [MIC] ≥ 2 µg/mL). However, the clinical implications are uncertain because fidaxomicin achieves high concentrations in the intestinal tract. METHODS: In an acute care hospital, we conducted a 3-year cohort study of patients with...

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PMID: 40036727
DOI: 10.1093/cid/ciaf028
PMCID: PMC13460438

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