Article
The Spore Coat Protein CotE Facilitates Host Colonization by Clostridium difficile.
The Journal of infectious diseases - 12 Dec 2017
Hong Huynh A, Ferreira William T, Hosseini Siamand, Anwar Saba, Hitri Krisztina, Wilkinson Anthony J, Vahjen Wilfried, Zentek Jürgen, Soloviev Mikhail, Cutting Simon M
Abstract excerpt
Clostridium difficile infection (CDI) is an important hospital-acquired infection resulting from the germination of spores in the intestine as a consequence of antibiotic-mediated dysbiosis of the gut microbiota. Key to this is CotE, a protein displayed on the spore surface and carrying 2 functional elements, an N-terminal peroxiredoxin and a C-terminal chitinase domain. Using isogenic mutants, we show in vitro...
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