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Article

High-altitude deer mouse hypoxia-inducible factor-2α shows defective interaction with CREB-binding protein.

The Journal of biological chemistry - 1 Jan 2000

Song Daisheng, Bigham Abigail W, Lee Frank S

Abstract excerpt

Numerous mammalian species have adapted to the chronic hypoxia of high altitude. Recent genomic studies have identified evidence for natural selection of genes and associated genetic changes in these species. A major gap in our knowledge is an understanding of the functional significance, if any, of these changes. Deer mice (Peromyscus maniculatus) live at both low and high altitudes in North America, providing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33639161
DOI: 10.1016/j.jbc.2021.100461
PMCID: PMC8024697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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