Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-α36 axis.

The Journal of pathology - 1 Jun 2021

Wang Yuxing, Pan Xiaohua, Li Yanjun, Wang Ru, Yang Yuanyuan, Jiang Baichun, Sun Gongping, Shao Changshun, Wang Molin, Gong Yaoqin

Abstract excerpt

Tamoxifen (TAM) resistance is a significant clinical challenge in endocrine therapies for estrogen receptor (ER)-positive breast cancer patients. Cullin 4B (CUL4B), which acts as a scaffold protein in CUL4B-RING ubiquitin ligase complexes (CRL4B), is frequently overexpressed in cancer and represses tumor suppressors through diverse epigenetic mechanisms. However, the role and the underlying mechanisms of CUL4B in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Hormonal
Share to Cullin Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Gene Knockdown Techniques

Share to Histone Deacetylases

Share to Tamoxifen

Share to Ubiquitination

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 33638154
DOI: 10.1002/path.5657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-α36 axis.PMID 33638154Read ↗

The natural L370F ERα variant confers endocrine resistance and sensitivity to ATRA in metastatic breast cancer cells.Semantic proximity Read ↗

The natural L370F ERα Variant Confers Endocrine Resistance and Sensitivity to ATRA in Metastatic Breast Cancer CellsSemantic proximity Read ↗

A predictive endocrine resistance index accurately stratifies luminal breast cancer treatment responders and nonresponders.Semantic proximity Read ↗

miR-449a Suppresses Tamoxifen Resistance in Human Breast Cancer Cells by Targeting ADAM22Semantic proximity Read ↗

RRM2 as a Key Biomarker and Therapeutic Target in Letrozole-Resistant ER+ Breast Cancer: Insights from Bioinformatics and Molecular DockingSemantic proximity Read ↗

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine ResistanceSemantic proximity Read ↗

Tamoxifen protects breast cancer patients from COVID-19: first evidence from real world dataSemantic proximity Read ↗

Prognostic potential of CUL3 ligase with differential roles in luminal A and basal type breast cancer tumorsSemantic proximity Read ↗

ELOVL2: a novel tumor suppressor attenuating tamoxifen resistance in breast cancerSemantic proximity Read ↗

miR-489 Confines Uncontrolled Estrogen Signaling Through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast CancerSemantic proximity Read ↗

Mechanisms of aromatase inhibitor resistance.Semantic proximity Read ↗

Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.