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Regulation of MYB by distal enhancer elements in human myeloid leukemia

26 Feb 2021

Abstract excerpt

MYB plays vital roles in regulating proliferation and differentiation of hematopoietic progenitor cells, dysregulation of MYB has been implicated in the pathogenesis of leukemia. Although the transcription of MYB has been well studied, its detailed underlying regulatory mechanisms still remain elusive. Here, we detected the long-range interaction between the upstream regions, -34k and -88k, and the MYB promoter...

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PMID: 33637692
DOI: 10.1038/s41419-021-03515-z

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