Article
Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first- and second-line ART in Tanzania.
The Journal of antimicrobial chemotherapy - 28 Oct 2022
Henerico Shimba, Lyimo Eric, Makubi Abel N, Magesa Daniel, Desderius Bernard, Mueller Andreas, Changalucha John, Kalluvya Samuel E, Van Zyl Gert, Preiser Wolfgang, Mshana Stephen E, Kasang Christa
Abstract excerpt
INTRODUCTION: Sub-Saharan African countries are introducing integrase strand transfer inhibitors (INSTIs) in their ART programmes as the preferred first-line regimen, and dolutegravir is the INSTI of choice due to its potency, tolerability and high genetic barrier to resistance. Dolutegravir was introduced into the first-line ART regimen in Tanzania in 2019. However, there is a paucity of data on the occurrence...
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