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Article

Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern uganda by high-resolution melt analysis.

Malaria journal - 25 Feb 2021

Kassaza Kennedy, Long Anna C, McDaniels Jennifer M, Andre Mharlove, Fredrickson Wasswa, Nyehangane Dan, Orikiriza Patrick, Operario Darwin J, Bazira Joel, Mwanga-Amumpaire Juliet A, Moore Christopher C, Guler Jennifer L, Boum Yap

Abstract excerpt

BACKGROUND: Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt). Following CQ withdrawal for anti-malarial treatment, studies across malaria-endemic countries have shown a range of responses. In some areas, CQ sensitive parasites re-emerge, and in others, mutant haplotypes persist. Active surveillance of resistance mutations in clinical parasites is...

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Identifiers

PMID: 33632242
DOI: 10.1186/s12936-021-03657-7
PMCID: PMC7908690

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