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Identifying Recrudescent Plasmodium falciparum in Treated Malaria Patients by Real-time PCR and High Resolution Melt Analysis of Genetic Diversity.

Scientific reports - 4 Jul 2018

Beshir Khalid B, Diallo Nouhoum, Sutherland Colin J

Abstract excerpt

Recurrent parasitaemia during follow up of clinical trials of antimalarial drug efficacy results from either recrudescence of parasites surviving treatment or from parasites newly emerging from the hepatic stage of infection. Nested PCR is used to distinguish these two possibilities and the technique is difficult to standardise. There is risk of both false positive and false negative results, leading to...

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Identifiers

PMID: 29973679
DOI: 10.1038/s41598-018-28179-2
PMCID: PMC6031682

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