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Mutational Biosynthesis of Hitachimycin Analogs Controlled by the β-Amino Acid-Selective Adenylation Enzyme HitB.

ACS chemical biology - 19 Mar 2021

Kudo Fumitaka, Takahashi Sotaro, Miyanaga Akimasa, Nakazawa Yuichiro, Nishino Kota, Hayakawa Yuki, Kawamura Koichi, Ishikawa Fumihiro, Tanabe Genzoh, Iwai Naeko, Nagumo Yoko, Usui Takeo, Eguchi Tadashi

Abstract excerpt

Hitachimycin is a macrolactam antibiotic with an (S)-β-phenylalanine (β-Phe) at the starter position of its polyketide skeleton. (S)-β-Phe is formed from l-α-phenylalanine by the phenylananine-2,3-aminomutase HitA in the hitachimycin biosynthetic pathway. In this study, we produced new hitachimycin analogs via mutasynthesis by feeding various (S)-β-Phe analogs to a ΔhitA strain. We obtained six hitachimycin...

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PMID: 33625847
DOI: 10.1021/acschembio.1c00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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