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Article

Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity.

PLoS pathogens - 1 Feb 2021

Cox Robert M, Sourimant Julien, Govindarajan Mugunthan, Natchus Michael G, Plemper Richard K

Abstract excerpt

Morbilliviruses, such as measles virus (MeV) and canine distemper virus (CDV), are highly infectious members of the paramyxovirus family. MeV is responsible for major morbidity and mortality in non-vaccinated populations. ERDRP-0519, a pan-morbillivirus small molecule inhibitor for the treatment of measles, targets the morbillivirus RNA-dependent RNA-polymerase (RdRP) complex and displayed unparalleled oral...

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Identifiers

PMID: 33621266
DOI: 10.1371/journal.ppat.1009371
PMCID: PMC7935272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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