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Article

Target analysis of the experimental measles therapeutic AS-136A.

Antimicrobial agents and chemotherapy - 1 Sept 2009

Yoon Jeong-Joong, Krumm Stefanie A, Ndungu J Maina, Hoffman Vanessa, Bankamp Bettina, Rota Paul A, Sun Aiming, Snyder James P, Plemper Richard K

Abstract excerpt

No effective therapeutic is currently in place for improved case management of severe measles or the rapid control of outbreaks. Through high-throughput screening, we recently identified a novel small-molecule class that potently blocks activity of the measles virus (MeV) RNA-dependent RNA polymerase (RdRp) complex in transient replicon assays. However, the nature of the block in RdRp activity and the physical...

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Identifiers

PMID: 19528268
DOI: 10.1128/AAC.00503-09
PMCID: PMC2737882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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